Biological characteristics of NKTcells and theirroles in anti-tumorimmunity
10.3872/j.issn.1007-385x.2019.08.015
- VernacularTitle:NKT细胞的生物特性及其在抗肿瘤免疫中的作用
- Author:
GUO Weichun
1
,
2
;
LIANG Junqing
1
,
2
;
JIA Shaochang
3
Author Information
1. Graduate School of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous region 01005910. People'
2. s Hospital affiliated to Inner Mongolia Medical University / Scientific Research Department of Cancer Hospital of Inner Mongolia Autonomous region
3. Department of Biotherapy, Army Cancer Center, Eastern Theater General Hospital
- Publication Type:Review
- Keywords:
NKT细胞；抗肿瘤；肿瘤免疫治疗
- From:
Chinese Journal of Cancer Biotherapy
2019;26(8):921-924
- CountryChina
- Language:Chinese
-
Abstract:
NKT细胞是一类特殊的T淋巴细胞亚群，既表达NK 细胞受体，也表达T细胞的相关受体。NKT细胞在多种免疫应答 的调节中发挥重要作用，包括感染、自身免疫性疾病、代谢性疾病和癌症，其通过连接固有免疫系统和适应性免疫系统显示出强大 的抗肿瘤活性。NKT细胞不仅能杀伤肿瘤细胞，也可激活其他抗肿瘤免疫细胞间接地发挥抗肿瘤作用，还能在肿瘤微环境中激活 衰竭的免疫细胞，在抗肿瘤免疫中发挥重要的作用。本文就NKT细胞的生物学特性及其在抗肿瘤免疫中的作用作一综述。
- Full text:20190815.txt
