Exploring the causal relationship between hip circumference and type 2 diabetes based on mendelian randomization
10.16462/j.cnki.zhjbkz.2020.01.003
- Author:
Wen-chao LI
1
;
Hong-kai LI
;
Xin-hui LIU
;
Shu-cheng SI
;
Yuan-yuan YU
;
Yun-xia LI
;
Tong-hui YUAN
;
Lei HOU
;
Lu LIU
;
Yu-chang ZHOU
;
Fu-zhong, XUE
Author Information
1. Department of Biostatistics, School of Public Health, Shandong University and Healthcare Big Data Institute of Shandong University, Jinan 250012, China
- Publication Type:Research Article
- Keywords:
Mendelian randomization;
Hip circumference;
Type 2 diabetes mellitus;
Causal inference
- From:
Chinese Journal of Disease Control & Prevention
2020;24(1):9-13,19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal association between hip circumference (HC) and type 2 diabetes mellitus (T2DM) based on Mendelian randomization. Methods The genetic variants data of the HC and T2DM from the Genetic Investigation of Anthropometric Traits (GIANT) and DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) database were matched according to the single nucleotide polymorphism (SNP) rsID. Genetic loci strongly related to the HC were used as instrumental variables; and the inverse-variance weighting, MR-Egger regression model and weighting median method were carried out to analyze the causal effect of HC on T2DM. Results Fifty-two, nine and fifteen SNPs were matched in the total cohort, female cohort and male cohort, respectively. Heterogeneity test suggested the SNPs were homogeneous. We found HC to be positively associated with T2DM risk (OR=1.065, 95% CI: 1.030-1.100, OR=1.103, 95% CI: 1.057-1.150 and OR=1.583, 95% CI: 1.273-1.968, respectively) in above three cohorts, respectively. Sensitivity analysis showed the results were robust. Conclusions There is a relationship between HC and T2DM of people, and HC may be the risk factor of T2DM.
