Advances in research of angiogenesis inhibitors combined with immune checkpoint inhibitors in the treatment of malignant tumors
10.3872/j.issn.1007-385x.2019.09.013
- VernacularTitle:抗血管生成药物联合免疫检查点抑制剂治疗恶性肿瘤的研究进展
- Author:
NIU Zhicheng
1
;
HE Dongwei
1
;
WANG Zhiyu
1
Author Information
1. Department of Oncology and Immunology, the fourth Hospital of Hebei Medical University
- Publication Type:Journal Article
- Keywords:
抗血管生成治疗;免疫检查点抑制剂;联合治疗;恶性肿瘤
- From:
Chinese Journal of Cancer Biotherapy
2019;26(9):1012-1018
- CountryChina
- Language:Chinese
-
Abstract:
肿瘤的生长需要血管的生成,不同于正常的血管,异常的肿瘤血管通过改变肿瘤微环境来抑制机体的免疫功能,从而 使肿瘤发生免疫逃逸。抗血管生成治疗可以使肿瘤血管正常化,进而改善机体的免疫功能。免疫检查点抑制剂通过改变肿瘤微 环境,不仅可以提高机体的免疫功能,同时也可以促进肿瘤血管的正常化。本文综述了抗血管生成治疗联合免疫检查点抑制剂 治疗恶性肿瘤的理论依据以及相关的临床数据,为恶性肿瘤的治疗提供更多的治疗策略。
- Full text:20190913.pdf