Application and prospect of nano-antibody in the diagnosis and treatment of cancers

VernacularTitle:纳米抗体在肿瘤诊断和治疗中的应用及其前景
Author: WANG Guan ^{1
,

2} ; XU Wenjuan ³ ; JIANG Guosheng ⁴
Author Information

1. (1. University of Chinese Academy of Sciences, Beijing 100049, China
2. 2. Wuhan Institute of Physics and Mathematics, InnovationAcademy for PrecisionMeasurementScienceandTechnology, ChineseAcademyofSciences
3. Medical Laboratory Center, Yantai Protgen Medical Testing Co., Ltd.
4. Institute of Immunology and Biotechnology Transformation, Binzhou Medical College
Publication Type:Journal Article
Keywords: nano-antibody; tumor; diagnosis; treatment; application
From: Chinese Journal of Cancer Biotherapy 2019;26(10):1053-1061
CountryChina
Language:Chinese
Abstract: Nano-antibodies (Nbs) were first discovered in the peripheral blood of alpacas. Compared with traditional antibodies, Nbs have the characteristics of small volume, good stability, strong tissue permeability, and easy production through microbial systems, etc. They are currently the smallest known functional antigen-specific binding fragments. Therefore, Nbs have been considered as valuable proteins in recent years and widely used in many fields, such as basic research, new drug development, disease treatment and so on. This article reviews the structural and biochemical properties of Nbs and the research progress on Nbs in the fields of tumor diagnosis and treatment, as well as their application prospect.
Full text:20191001.pdf