Roles of microRNAs in the tumor progression promoted by cancer-associated fibroblasts
10.3872/j.issn.1007-385x.2019.11.001
- VernacularTitle:MicroRNAs在肿瘤相关成纤维细胞促进肿瘤发展进程中的作用
- Author:
GUO Xueru
1
;
XU Ke
1
Author Information
1. Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital
- Publication Type:Journal Article
- Keywords:
microRNA;
tumor microenvironment (TME);
cancer-associated fibroblast (CAF);
tumor progression;
cytokine
- From:
Chinese Journal of Cancer Biotherapy
2019;26(11):1181-1188
- CountryChina
- Language:Chinese
-
Abstract:
Cancer-associated fibroblasts (CAFs) are one of the major cellularcomponents in tumor microenvironment (TME), which play an important role in cancer progression. MicroRNAs (miRNAs) could participate in the process of CAFs, transformation and metabolism reprogramming, affect the stemness of CAFs, and regulate CAFs-mediated tumor cell proliferation, invasion and chemotherapy resistance; and studies have shown that miRNAs play an important role in CAFs formation and the regulation of CAFs on tumors. The miRNAs released by CAFs can be used as reference indicators for tumor diagnosis, prognosis and drug selection. Thus, exploring the role of miRNAs in the interaction between CAFs and tumor cells and underlining the mechanism, is of great significancefor understanding the occurrence and development of tumors, as well as providing novel strategy for cancer treatment. This review will summarize the role of miRNAs in the formation of CAFs and the regulation of CAFs on tumor cells.
- Full text:20191101.pdf
