Mechanism of regularatory T cells in tumor immunity and the new strategy of treatment
10.3872/j.issn.1007-385x.2019.12.015
- VernacularTitle:调节性T细胞在肿瘤免疫中作用机制及治疗新策略的研究进展
- Author:
XIAO Wenlu
1
;
JIANG Jingting
2
;
LU Binfeng
3
Author Information
1. Department of Medicine, Suzhou University
2. Tumor Biological diagnosis and treatment Center of the third affiliated Hospital of Suzhou University, Jiangsu tumor Immunotherapy Engineering Technology Research Center, Cell Therapy Research Institute of Suzhou University
3. Department of Medicine, Suzhou University,Tumor Biological diagnosis and treatment Center of the third affiliated Hospital of Suzhou University, Jiangsu tumor Immunotherapy Engineering Technology Research Center, Cell Therapy Research Institute of Suzhou University
- Publication Type:Review
- Keywords:
肿瘤；调节性T细胞；免疫治疗
- From:
Chinese Journal of Cancer Biotherapy
2019;26(12):1387-1391
- CountryChina
- Language:Chinese
-
Abstract:
调节性T（regulatory T，Treg）细胞是一类控制体内免疫反应性的T细胞亚群，在维持机体的免疫系统稳态和调节免疫 应答方面具有重要作用，并且发现在多种肿瘤类型中以较高比例存在，被认为是产生抗肿瘤免疫应答的主要障碍。Treg细胞在 其功能状态和稳定性方面存在异质性，通过多种机制发挥免疫负调控作用，目前在自身免疫和肿瘤免疫的研究中发现，特异性调 节不同Treg细胞群体可改善免疫疗效。但是，如何更加合理有效的以Treg细胞为靶点抑制肿瘤的进展仍需进一步探索。本文就 Treg细胞在肿瘤免疫中的作用机制及治疗应用新策略展开综述。
- Full text:20191215.pdf
