Research progress on the regulatory mechanism of hepatic inflammation-induced carcinogenesis
10.3872/j.issn.1007-385x.2020.01.001
- VernacularTitle:肝脏炎癌转化调控机制的研究进展
- Author:
WANG Suyuan
1
,
2
;
HOU Jin
1
,
2
Author Information
1. National Key Laboratory of Medical Immunology &
2. Institute of Immunology, Naval Military Medical University
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma (HCC);
inflammation;
inflammation-induced carcinogenesis;
immune cell;
regulatory molecules;
signaling pathway
- From:
Chinese Journal of Cancer Biotherapy
2020;27(1):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Uncontrolled chronic inflammation plays key roles in the carcinogenesis of hepatocellular carcinoma (HCC). Among the risk factors of HCC, such as chronic viral hepatitis, alcoholic hepatitis, non-alcoholic steatohepatitis and so on, the occurrence and development of uncontrolled chronic inflammation are the core factors of HCC. The damaged or dead hepatocytes generated during the process of chronic inflammation may lead to the activation of immune cells in the liver, resulting in hepatic inflammation. Chronic and prolonged liver inflammation promotes the occurrence of cancer. During this process, different injuries or death patterns of hepatocytes and progression of inflammation caused by activation of different immune cells play different roles in hepatic carcinogenesis, involving multiple pathological or pathophysiological processes such as liver injury, inflammation, and compensatory proliferation, as well as function alteration of various cells, signaling pathways, and regulatory molecules. Further studies on the regulatory mechanisms of hepatic inflammation-induced carcinogenesis are helpful to provide theoretical basis for the intervention of occurrence of HCC. This review focused on the research progress of regulatory mechanisms involved in the hepatic inflammation-induced carcinogenesis.
- Full text:20200101.pdf
