Research Progress of Epigenetics in Pathogenesis and Treatment of Malignant Tumors.

Author: Pan WANG ¹ ; Honglin ZHAO ¹ ; Fan REN ¹ ; Qingchun ZHAO ¹ ; Ruifeng SHI ¹ ; Xingyu LIU ¹ ; Jinghao LIU ¹ ; Yongwen LI ¹ ; Ying LI ¹ ; Hongyu LIU ¹ ; Jun CHEN ¹
Author Information

1. Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin Lung Cancer Institute, Tianjin Key Laboratory of lung Cancer Metastasis and Tumor Microenvironment, Tianjin 300052, China.
Publication Type:Journal Article
Keywords: Drug combinations; Epigenetic therapy; Epigenomics; Neoplasms
From: Chinese Journal of Lung Cancer 2020;23(2):91-100
CountryChina
Language:Chinese
Abstract: Epigenetic modification is closely related to the occurrence and development of tumors. It mainly regulates gene function and expression level through DNA methylation, histone modification, regulation of non-coding RNA and chromatin structure reconstruction. At present, epigenetic drugs have been gradually applied to the treatment of malignant tumors. Common drug types include: DNA methyltransferase inhibitors and histone deacetylase inhibitors. However, these drugs still have many shortcomings and a wide range of clinical applications need further research. Encouragingly, the epigenetic drugs in combination with various anti-tumor drugs have shown great application potential. In this paper, we summarized the development mechanism of epigenetics in malignant tumors and the progress of related drugs.