Role of JAK2/STAT3 signaling pathway in microglia activation after hypoxic-ischemic brain damage.
10.12200/j.issn.1003-0034.2020.02.0201
- Author:
Jie ZENG
1
;
Ya-Lin ZHAO
1
;
Bo-Wen DENG
1
;
Xiao-Ye LI
1
;
Jie XU
1
;
Le WANG
1
;
Xiao-Hong MU
1
Author Information
1. The Fourth Department of Orthopaedics, the First Affiliated Hospital of Beijing Chinese Medical University, Beijing 100700, Beijing, China.
- Publication Type:Journal Article
- Keywords:
Hypoxic-ischemic encephalopathy;
JAK2/STAT3 signaling pathway;
Microglia;
Neuroinflammation
- From:
China Journal of Orthopaedics and Traumatology
2020;33(2):190-194
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxic-ischemic encephalopathy (HIE) is the leading cause of neonatal death and neurodevelopmental disorders in infants. Part of patients have different degrees of neurological sequelae, such as cerebral palsy, cognitive and motor function development disorders. Hypoxia-ischemia may activate JAK2/STAT3 signaling pathway, which leads to the microglia activation and neuroinflammation. Down-Regulating JAK2/STAT3 signaling pathway can inhibit microglia activation and regulate the inflammatory injury of nervous system. At present, the treatment of hypoxic ischemic encephalopathy is limited, so the study of regulatory mechanism about microglia activation has important value for the treatment of hypoxic-ischemic encephalopathy. This paper summarizes the role of JAK2/STAT3 signaling pathway in microglia activation and analyzes the relationship between them, in order to provide new ideas and strategies for treatment on hypoxic-ischemic encephalopathy.
