Correlations of serum CEA and CA19-9 levels with clinical staging of colorectal cancer
10.19485/j.cnki.issn2096-5087.2018.01.006
- VernacularTitle:结直肠癌患者临床分期与CEA和CA19-9的相关性分析
- Author:
Li-Hua ZHANG
1
;
Si-Meng GU
;
Ding YE
;
Yu-Ping ZHANG
;
Zhen-Jun LI
;
Xiao-Jiang YING
Author Information
1. 绍兴市人民医院肛肠外科
- Keywords:
Colorectal cancer;
Tumor marker;
TNM staging;
CEA;
CA19-9
- From:
Journal of Preventive Medicine
2018;30(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of serum CEA and CA19-9 concentration for clinical staging of colorectal cancer. Methods A total of 350 patients who underwent the surgical treatments for colorectal cancer between February 2015 to January 2017 were enrolled. The serum CEA and CA19-9 were detected by chemoluminescence method. Results The positive rate of CEA of patients in stageⅠto Ⅳ was 25.00%, 36.69%, 50.78% and 66.67%, respectively. The positive rate of CA19-9 of patients in stageⅠto Ⅳwas 2.94%, 10.07%, 17.97% and 53.33%, respectively. The positive rates of CEA and CA19-9 were gradually increased with the stage developing (P<0.05). Results from multivariate logistic regression analysis showed that the positive levels of CEA and CA19-9 were risk factors in the TNM staging of colorectal cancer. The ORs and 95%CI were 1.790 (1.163-2.755)and 3.476(1.790-6.749), respectively. Conclusion The positive serum concentrations of CEA and CA19-9 showed significant associations with TNM staging. Preoperative serum concentrations of CEA and CA 19-9 could be auxiliary diagnostic indicators to assess the condition of colorectal cancer.