The relationship between the level of serum lipid and homocysteine with cerebral infarction
10.19485/j.cnki.issn1007-0931.2017.12.010
- VernacularTitle:脑梗死与血脂及同型半胱氨酸水平的相关性研究
- Author:
Rui-Hao WU
1
;
Xing-Xing ZHOU
;
Wu ZHOU
;
Hong-Xiang TU
;
Tie-Li ZHOU
Author Information
1. 温州医科大学附属第一医院医学检验中心
- Keywords:
Cerebral infarction;
Homocysteine;
Blood lipid;
Atherosclerosis index
- From:
Journal of Preventive Medicine
2017;29(12):1231-1234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between cerebral infarction and homocysteine (Hcy) level and atherosclerosis index (ASI) , and to provide reference for prevention and treatment of cerebral infarction. Methods 2525 patients hospitalized with cerebral infarction and 8151 healthy subjects were included in the study, the blood serum homocysteine and blood lipid levels were detected by enzymatic cycling and enzymatic method, and the ASI was calculated according to the results of blood lipid test. The risk factors of cerebral infarction were analyzed by logistic regression analysis model. Results The Physical examination Health Group male 4952, female 3199, average (45.65±10.77) years old, in the cerebral infarction Group male 1590 cases, female 935, average (65.47±12.16) years old. A total of 360 patients with high homocysteine were detected in the Health examination group, the detection rate was 4.42%, the cerebral infarction group detected 268 patients with high homocysteine, the detection rate was 10.61%, and the difference was statistically significant (P<0.01) . Logistic regression analysis showed that age (OR=1.147, 95%CI: 1.140~1.154), homocysteine (OR=1.022, 95% CI: 1.010 ~1.035) and total cholesterol (OR=2.815, 95% CI: 2.603 ~3.045) level, ASI (OR=1.914, 95%CI: 1.794~2.042) are the risk factors of cerebral infarction, women (OR=0.694, 95%CI: 0.606~0.697) are the protective factors for the occurrence of cerebral infarction. Conclusion Serum homocysteine and total cholesterol levels, ASI elevated can increase the risk of cerebral infarction, regular detection of serum homocysteine and lipid levels can help early detection and prevention of cerebral infarction.
