A study on the Xylo-oligosaccharides in combination with chitooligosaccharides in protecting mice from alcohol-induced liver injury and modulate immune function in mice
10.19485/j.cnki.issn1007-0931.2017.07.008
- VernacularTitle:低聚木糖联合壳寡糖保护小鼠急性肝损伤及提高脾脏细胞免疫活性的作用
- Author:
Yan-Hua SONG
1
;
De-Lei CAI
;
Yong XIA
;
Wei LU
;
Jian-Yun FU
;
Cai-Ju XU
Author Information
1. 浙江省疾病预防控制中心
- Keywords:
Xylo-oligosaccaride;
Chitooligosaccharides;
Liver injury;
Immune function
- From:
Journal of Preventive Medicine
2017;29(7):684-688
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of xylo-oligosaccharides with chitooligosaccharides on alcohol-induced liver injury and immune function in mice. Methods Different doses of chitosan oligosaccharide (0.045 g/kg-0.26 g/kgB.W) and xylo-oligosaccaride (0.055 g/kg-0.32 g/kgB.W) were feed to the mice for 30 days. The mice live-injury model was induced by alcohol. MDA、 GSH、 TG level in liver and T lymphocyte proliferation of spleen cells induced by conA, the antibody-producing cells, and natural killer (NK) activity were detected. Results Compared with the live-injury model group, MDA level of low/middle dose group, TG level of middle dose group and pathological evaluation score of liver steatosis of high dose group in mice liver were decreased because of chitosan oligosaccharide and xylo-oligosaccaride feeding. Compared with the control group, the ability of T lymphocyte proliferation of mouse spleen induced by ConA and the antibody-producing cells were increased in mice of middle and high dose group. The differences had statistical significances (P<0.05) . Conclusion Under this experimental condition, xylo-oligosaccharides in combination with chitooligosaccharides could protect the mice from alcohol-induced liver injury and enhance immune function in spleen of normal mice synergistically.
