A study on the correlations study among HOMA-IR, obesity and inflammatory factors among middle aged and elderly population
10.19485/j.cnki.issn1007-0931.2017.05.007
- VernacularTitle:血糖正常中老年人胰岛素抵抗指数分布及影响因素分析
- Author:
Xiao-Feng SHI
1
;
San-Zhong WANG
;
Xin-Fen YU
;
Hua SHEN
;
Qin-Mei PAN
;
Zhi-Xing SHEN
;
Di-Sheng SHEN
;
Gong-Ying CHEN
Author Information
1. 湖州市南浔区练市医院
- Keywords:
HOMA-IR;
Insulin resistance;
Obesity;
Inflammatory factor
- From:
Journal of Preventive Medicine
2017;29(5):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of insulin resistance (HOMA-IR) index and its influencing factorsamong middle and old aged people with normal glucose and to provide the basis for early screening and prevention of type 2diabetes. Methods A total of 229 residents were selected with health records showed normal blood glucose (fasting bloodglucose < 7.0mmol/L, postprandial 2h blood glucose<11.1 mmol/L) and more than 40 years old from July, 2012 to June,2015. Height, weight, waist and hip circumference, and the fasting plasma glucose (FPG), insulin (FINS), lowdensity lipoprotein (LDL), uric acid, tumor necrosis factor (TNF) and interleukin -6 (IL-6) were recorded to analyzethe distribution of HOMA-IR and its influencing factors. Results Totally 229 people were included, of which 113 were male(49.34%), 116 female(50.66%) . The average age was(63.58 + 8.85) years old. The average HOMA-IR index was 0.94(1.08) and there were 21 people that HOMA-IR exceed the standard (HOMA-IR≥2.68), accounting for 9.17%.TheHOMA-IR index of different gender, age, waist circumference, hip circumference, uric acid in the elderly had significantdifference (P < 0.05) .Multiple linear regression analysis showed that HOMA-IR index was positively correlated withfemale, waist circumference and IL-6 and was negatively correlated with age. Conclusion The possibility of IR was higherin women with relatively low age, female, central obesity and high IL-6 levels among the middle and old aged people withnormal blood glucose.
