Cardioprotection and mechanism of embelin in sepsis mice model
10.19485/j.cnki.issn1007-0931.2017.04.008
- VernacularTitle:蒽贝素对脂多糖诱导小鼠心脏炎症损伤的影响
- Author:
Xiang QIAN
1
;
Tao YAN
;
Yan QI
;
Ying-Ying CHEN
Author Information
1. 杭州市中医院
- Keywords:
Embelin;
Sepsis;
NF-κB;
TNF-α;
PPAR-γ
- From:
Journal of Preventive Medicine
2017;29(4):355-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of embelin on the cardiac injury in sepsis mice model, and to explore whether PPAR-participates in the mechanism of cardioprotection of embelin.Methods Male mice were randomly divided into five groups.Control group were received PBS i.p.injection.Sepsis model group were received LPS (10 mg/kg) i.p.injection.Embelin treatment groups were received LPS (10 mg/kg) i.p.injection, and after 30 min different doses of embelin were given (5, 10, and 20 mg/kg, i.p.).Results The serum cTnI level and TNF-α、NF-κB protein in low dose embelin (5 mg/kg) treatment mice was not different with that of the sepsis mice.But the serum cTnI level and TNF-α、NF-κB protein in middle and high doses embelin (10, 20 mg/kg) treatment mice was lower than that of sepsis mice, and the expression of PPAR-γ was higher(P<0.05).Conclusion Embelin could protect against sepsis-induced cardiac injury.The mechanism might be involved in the upregulation of PPAR-γ protein, inhibition of NF-κB activation,and reduction of TNF-α level.
