A meta -analysis of vaccine efficacy of haemophilus influenza type b vaccine among children under five years of age
- VernacularTitle:5岁以下儿童接种 b 型流感嗜血杆菌疫苗流行病学效果的 Meta 分析
- Author:
Yu HU
1
;
Qian LI
;
Bing ZHANG
;
Ya-Ping CHEN
Author Information
1. 浙江省疾病预防控制中心
- Keywords:
Haemophilus influenza type b Vaccine;
Basic immune program;
Vaccine protective efficacy;
Meta -analysis
- From:
Journal of Preventive Medicine
2016;28(12):1208-1213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate vaccine efficacy(VE)of Haemophilus influenza type b vaccine (Hib)among children under five years of age .Methods Searching “National Center for Biotechnology Information,NCBI”,“Cochrane Library, CL”,“China Biology Medicine disc,CBMd”,“China National Knowledge Infrastructure,CNKI”,“Wanfang Database, the studies of VE for Hib among children under five years of age were included,and meta -analysis were made by RevMan 5.3 software.Results A total of 9 studies were included,seven were randomised clinical trial(RCT)design and two were semi RCT design.The VEs of one dose,two doses and three doses of Hib were 65%(95%CI:23% -84%),79%(95%CI:54% -90%),and 85%(95%CI:77% -90%),respectively.Conclusion We found that Hib is highly effective and that the two dose regime is as good as the three dose regime.
