A study on the relationship between ApoB/ApoA1 and carotid intima -media thickness among obese children
- VernacularTitle:肥胖儿童载脂蛋白B／A1与颈总动脉内膜中层厚度的相关性分析
- Author:
Bo LUO
1
;
Gu XU
;
Fei RUAN
Author Information
1. 诸暨市人民医院
- Keywords:
Obesity;
Children;
Carotid intima -media thickness;
ApoB/apoA1
- From:
Journal of Preventive Medicine
2016;28(11):1110-1113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between ApoB/ApoA1 ratio and the common carotid arterial intima -media thickness (CCA IMT)among obese children.Methods A total of 53 obese children in the Zhuji People's hospital outpatient were enrolled as obese group.Other 59 no -obese healthy children were recruited as control group.Serum fasting glUAose (FG),fasting insulin (FI),total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL -C),low density lipoprotein cholesterol (LDL -C),lipoprotein A,apolipoprotein A1 (ApoA1 ), apolipoprotein B (ApoB),alanine aminotransferase (ALT),aspartate amino transferase (AST),and uric acid (UA) were measured in the clinical laboratory.Body mass index (BMI),waist to hipline (W/H)ratio,ApoB/ApoA1 ratio, insulin resistance by homeostasis model (HOMA -IR),and βcell function by homeostasis model (HOMA -β)were calculated.The common carotid arterial IMT of obese children was measured by B -mode ultrasound.All factors between two groups were compared by independent t test.The differences between the two groups were compared,and the correlation between CCA IMT and other factors in obesity group was analyzed by stepwise multiple regression model.Results In the obese group,lg(ALT),lg(AST),lg(UA),ln(10*TG),TC,LDL -C,ApoB,ApoB/ApoA1,lg(HOMA -β), and ln(10* HOMA -IR)were significantly higher than those in control group (P <0.05,respectively)while HDL -C and ApoA1 in obese group were lower than those in control group (P <0.01,respectively).Bivariate correlation analysis showed that CCA IMT was inversely correlated with ApoA1 and positively correlated with ApoB/ApoA1,lg(ALT),and lg (AST)(P <0.05,respectively).Analysis using multiple regression method showed that ApoB/ApoA1 was positively correlated with CCA IMT in these obese children (P <0.05 ).Conclusion In obese children,ApoB /ApoA1 was the independent determinant of CCA IMT,which may be a risk factor for atherosclerosis early in life.
