The implication of HDAC2 in diagnosis and treatment patients with acute exacerbation of chronic obstructive pulmonary disease
- VernacularTitle:组蛋白去乙酰化酶2在慢性阻塞性肺疾病急性加重期诊疗中的意义
- Author:
Wei-Biao WANG
1
;
Dai LI
;
Hong TENG
Author Information
1. 绍兴第二医院
- Keywords:
Chronic obstructive pulmonary disease;
Histone deacetylase 2;
C -reactive protein;
Proealeitonin;
Lung function
- From:
Journal of Preventive Medicine
2016;28(6):553-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation among the concentration of peripheral blood histone deacetylase 2 (HDAC2),C -reactive protein (CRP),proealeitonin (PCT)and lung function among patients with acute exacerbation period of chronic obstructive pulmonary disease (AECOPD).Methods A total of 60 patients with AECOPD were selected as the test group,and 40 healthy subjects in the same medical examination center were selected as the control group.The HDAC2,CRP,PCT,lung function testing and blood gas analysis were measured on Day 0,3,7,1 0.Results Along with the process of AECOPD patients,in the treatment of 0 d,3 d,7 d,1 0 d,the average level of CRP and PCT in peripheral blood of patients was decreased gradually,while the average level of HDAC2 was gradually increased (P<0. 05 ).In patients treated with 0 d,3 d,7 d,1 0 d,HDAC2 levels were negatively correlated with CRP and PCT at the same time (rCRP was-0. 31 6,-0. 435,-0. 495,-0. 547,respectively,and rPCT was -0. 41 4,-0. 332,-0. 481 ,-0. 523,respectively, P<0. 01 ).The level of HDAC2 was positively correlated with lung function in the same period (rFEV1 was 0. 594,and rFEV1/Expected value was 0. 561 ,P<0. 01 ).Conclusion HDAC2 may be a negative regulator of the inflammatory response among the patients with AECOPD,and is associated with the degree of airflow obstruction of the patients.
