Cytokines in Neonatal Sepsis.
- Author:
Hye Jin PARK
1
;
So Yeon KIM
;
Jun Hwa LEE
;
Eun Jin CHOI
;
Jin Kyung KIM
;
Sang Gyung KIM
;
Hai Lee CHUNG
;
Woo Taek KIM
Author Information
1. Department of Pediatrics, School of Medicine, Catholic University of Daegu, Daegu, Korea. wootykim@cu.ac.kr
- Publication Type:Original Article
- Keywords:
Sepsis;
Interleukin-1beta;
Interleukin-6;
Interleukin-8;
TNF-alpha;
Premature rupture of membrane
- MeSH:
Cytokines*;
Daegu;
Enzyme-Linked Immunosorbent Assay;
Humans;
Infant;
Infant, Newborn;
Intensive Care, Neonatal;
Interleukin-1beta;
Interleukin-6;
Interleukin-8;
Necrosis;
Risk Factors;
Rupture;
Sepsis*;
Tumor Necrosis Factor-alpha
- From:Korean Journal of Pediatrics
2004;47(5):515-520
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Maternal premature rupture of membrane(PROM) over 24 hours is a risk factor in neonatal sepsis and a main cause of administration to neonatal intensive care unit. Levels of proinflammatory cytokines were studied to diagnose and treat early in newborn infants with sepsis and with a history of maternal PROM. METHODS: Interleukin-1beta(IL-1beta), Interleukin-6(IL-6), Interleukin-8(IL-8), and tumor necrosis factor-alpha(TNF-alpha) were checked using ELISA kits in neonatal infants who were admitted to the Catholic University of Daegu from May, 2002 to Feb, 2003. We divided them into three sets of groups; sepsis group(n=26), PROM group(n=20), and control group(n=24). RESULTS: Levels of IL-1beta, IL-8, and TNF-alpha in the sepsis group were all significantly statistically different from the PROM and the control group, but there was no significant difference between the PROM group and the control group. Levels of IL-6 in the sepsis, the PROM, and the control group were all significantly statistically different from each other. CONCLUSION: Levels of IL-1beta, IL-6, IL-8, and TNF-alpha in the sepsis group increased but only levels of IL-6 in the PROM group increased. Thus we can use cytokines as a marker of neonatal sepsis, especially, in neonatal infants with a history of maternal PROM.
