A study on the effect of whole cranberry powder on immune function of ICR mice in vivo
- VernacularTitle:蔓越莓全果粉对小鼠免疫功能的影响
- Author:
Cai-Ju XU
1
;
Wei LU
;
Yan-Hua SONG
;
De-Lei CAI
;
Yong XIA
;
Yun-Yan ZHENG
Author Information
1. 浙江省疾病预防控制中心
- Keywords:
Whole cranberry powder;
Urinary tract infection;
Immuno -regulation;
Humoral immunity;
Macrophage phagocytosis
- From:
Journal of Preventive Medicine
2016;28(5):441-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toevaluatetheeffectsofwholecranberrypowder(Pacranpowder)onimmunefunctionsofICR miceinvivo.Methods FemaleICRmice(18-22g)wererandomlydividedintocontrolgroupandlow,mediumandhigh dose groups of whole cranberry powder (83,1 66,and 332 mg/kgbw).Whole cranberry powder was treated with by gavage for 30 days continuously.Control mice were treated with distilled water only.Their immune functions were analyzed, including serum hemolysin analysis, antibody -producing cells (APCs ), conA -induced splenic lymphocyte transformation,SRBC-induced delayed type hypersensitivity,natural killer cell activity assay,peritoneal macrophages phagocytosed chicken red blood cells (CRBC),carbon clearance test and thymus or spleen /body weight ratio.Results Ascomparedwiththecontrols,wholecranberrypowdertreatmentincreasedthenumberofplagueformingcells(PFCs)at 83 mg/kgbw group(P<0.05 ).There were no statistical difference in the total production of antibodies,the activity of conA-induced splenic lymphocyte transformation,the left-hind voix pedis thickness,NK cytoactivity,the phagocytosis index and ratio of peritoneal macrophages, the carbon clearance ability between the groups treated with different concentrationsofwholecranberrypowderandthecontrolgroup(P>0.05).Conclusion Wholecranberrypowdercan enhance mouse the number of plague forming cells (PFCs).
