A study on the association among serum insulin,IGFBP3, and endometrial cancer risk in Chinese women
- VernacularTitle:血清胰岛素和IGFBP3水平与子宫内膜癌相关性研究
- Author:
Jia-Min HUANG
1
;
Yan ZHANG
;
Shi-Ming LV
;
Qing-Qing WANG
Author Information
1. 浙江大学医学院附属妇产科医院检验科
- Keywords:
Endometrial carcinoma;
Insulin;
Insulin-like growth factor binding protein 3;
Obesity
- From:
Journal of Preventive Medicine
2016;28(4):358-361
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toexploretheassociationamongseruminsulin,IGFBP3,andendometrialcancerriskinChinese women.Methods SeruminsulinandIGFBP3weredetectedbyELISAmethodin206patientswithendometrialcarcinoma and 310 healthy women.Using logistic regression analysis after adjustments for BMI,serum glucose and triglycerides to exploretheassociationamongthetwoindicatorsandtheriskofendometrialcarcinoma.Results Increasedinsulinwere found in the women with endometrial carcinomas as compared with that of controls [Mean ±SD:insulin (14.84 ±16.72) uU·mL-1 in women with cancer versus (8.13 ±9.40)uU·mL-1 in controls,P<0.01].However,serum IGFBP3 was not significantly higher in women with endometrial cancer [Mean ±SD:IGFBP3 (1.76 ±2.44)mg·L-1 in women with cancer versus (1.57 ±1.80)mg·L-1in controls,P>0.05].The risk for endometrial cancer was significantly higher in the upper quartile relevant to the lowest quartile of serum insulin,and lower in the upper quartile of serum IGFBP3 (P<0.05).Logistic regression analysis showed that serum insulin was the risk factor of endometrial carcinoma(OR=2.34, 95%CI:1.32 -4.14),after adjusting obesity/overweight status,serum glucose,total cholesterol,total glyceride,and HDL-C.Conclusion HyperinsulinemiawasanindependentriskfactorforendometrialcarcinomasinChinesewomen. However,the protective role of increased serum IGFBP3 should be validated further.
