An analysis on the expression level and influencing factors of CD4 +CD25 + regulatory cells among male drug -abusers with syphilis
- VernacularTitle:吸毒男性梅毒感染者 CD4＋CD25＋调节性T细胞表达及影响因素分析
- Author:
Ying CONG
1
;
Xiu-Ying CHEN
;
Ying ZHOU
;
Yong-Liang LEI
;
Min LIU
;
Ling YE
;
Sha-Bin CHEN
Author Information
1. 丽水市疾病预防控制中心
- Keywords:
Syphilis infection;
Drug abuse;
CD4 + CD25 + regulatory T cell
- From:
Journal of Preventive Medicine
2015;(9):865-868
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression level and influencing factors of CD4 +CD25 + regulatory cells(Treg)among male drug -abusers with syphilis.Methods 144 male drug -abusers with syphilis,41 male drug -abusers without syphilis,35 male non -drug abuser with syphilis and 35 male healthy volunteers were enrolled in this study.Expression levels of CD4 +CD25 +Treg of them were detected.A questionnaire interview was conducted among these participants, including drug abuse duration,drug types and abuse ways.Results The levels of Treg expression of drug -abusers with syphilis were significantly higher than that of drug -abusers without syphilis and non -drug abuser with syphilis (P <0.01 ).Despite of the stage of syphilis,types of drugs and abuse way,Treg expression levels with drug abuse duration of"above 1 -year"were significantly higher than those of "1 -year or below"(P <0.01 ).Treg expression levels were positively correlated to drug abuse duration (R2 =0.672,P <0.01)among patients.Among the participants,people both with traditional and new drugs were significantly higher than that with only traditional or new drug (P <0.01).In addition, people both with injecting and non -injecting abuse were significantly higher than that with one way of drug -abuse (P <0.01).Among those with drug abuse duration of "above 1 -year",Treg levels of drug -abusers with traditional drugs and injecting abuse way were remarkably higher than that with new drug and non -injecting abuse respectively (P <0.01). Conclusion Among male drug -abusers with syphilis,suppression of cellular immune function resulting from increased CD4 +CD25 +regulatory T cells is related to drug abuse duration,and is also influenced by drug types and abuse ways.
