Clinical Outcomes of Increased Nuchal Translucency in Three Years.
- Author:
Min Hyoung KIM
1
;
Su Hyun PARK
;
Sun Hwa CHA
;
Yon Ju KIM
;
Myoung Jin MOON
;
Jin Hoon CHUNG
;
June Seek CHOI
;
Joo Oh KIM
;
Joong Sik SHIN
;
Hyun Kyung AHN
;
Jung Yeol HAN
;
Hyun Mee RYU
;
Jae Hyug YANG
;
Kyu Hong CHOI
;
Young Ho LEE
;
Moon Young KIM
Author Information
1. Department of Obstetrics and Gynecology, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Nuchal translucency;
Chromosomal abnormality;
Abnormal pregnancy outcome
- MeSH:
Abnormal Karyotype;
Abortion, Spontaneous;
Amniocentesis;
Chromosome Aberrations;
Female;
Fetal Death;
Fetus;
Gestational Age;
Humans;
Karyotype;
Nuchal Translucency Measurement*;
Pregnancy;
Pregnancy Outcome;
Pregnancy Trimester, Second;
Retrospective Studies;
Ultrasonography
- From:Korean Journal of Obstetrics and Gynecology
2003;46(11):2151-2155
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the relationship between increased nuchal translucency (NT) and abnormal pregnancy outcomes. METHODS: From January 1999 to December 2001, The 298 fetuses of increased nuchal translucency (>or=2.5 mm) in period of 10-14 weeks gestation were reviewed retrospectively. Amniocentesis and high resolution ultrasonography during second trimester were done for all cases. We analyzed septation within NT, karyotypes, structural anomalies, and adverse pregnancy outcomes such as spontaneous abortion, intrauterine fetal death and preterm delivery. RESULTS: The mean age of the patients was 30.5 +/- 3.5 years. The mean gestational age and CRL were 12.5 +/- 0.95 weeks and 6.5 +/- 1.15 mm. We observed 18 (6%) cases of abnormal karyotypes. 7/46 (15.2%) fetuses with internal septation had abnormal karyotype and 11/252 (4.4%) fetuses without internal septation had abnormal karyotype (p=0.013). Among the 280 fetuses with normal karyotype, 8 (2.8%) fetuses had structural anomalies and 18 (6.4%) fetuses had adverse pregnancy outcomes. The chromosomal abnormality and structural anomaly were significantly increased in the group of nuchal translucency thickness above 3.5 mm (p=0.001). CONCLUSION: Increased nuchal translucency is related with chromosomal abnormality and abnormal pregnancy outcomes.
