The effects of gutter oil on liver function,renal function and serum lipid metabolism in mice
- VernacularTitle:地沟油对小鼠肝肾功能及脂肪代谢的影响
- Author:
Yue-Min DING
1
;
Xing-Xing ZHU
;
Cheng HUANG
;
Jia-Lu CHEN
;
Li-Mei FAN
;
Zhen-Dong SHI
Author Information
1. 浙江大学城市学院医学院
- Keywords:
Gutter oil;
Liver function;
Renal function;
Serum lipid
- From:
Journal of Preventive Medicine
2015;(8):764-767
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of gutter oil on liver function,renal function and serum lipid metabolism in mice.Methods A total of 72 mice were averagely divided into 6 groups.Mice were gavaged with different dosages (5 μL/g,1 0 μL/g and 20 μL/g)of gutter oil or cooking oil every other day for continuing 8 weeks.The indexes of liver, kidney and serum lipid parameters were assayed.Results The moisture,acid value and peroxide value of the gutter oil exceeded the national standard.After continuing 8 weeks'intake of oils,alanine aminotransferase (ALT)of gutter oil group with a dosage of 5 μL/g,as well as aspartate aminotransferase (AST)of gutter oil group with a dosage of 1 0 μL/g significantly increased (P <0.05),compared with the cooking oil group.Serum creatinine (Scr)of the gutter oil groups with 3 dosages significantly increased compared with the control groups (P <0.05 ).Meanwhile,blood urea nitrogen (BUN)of gutter oil groups with a dosage of 5 μL/g and 1 0 μL/g were also significantly increased respectively(P <0.05). However,no significant differences were observed in triglyceride (TG)and total cholesterol (TC)among the groups. Conclusion Eight weeks'intake of gutter oil could cause the damage to liver and renal functions.
