Expression of TRAIL (Apo-2L)/TRAIL Receptor System Related to Apoptosis at the Human Extraembryonic Tissues and Gestational Trophoblastic Disease.
- Author:
In Bai CHUNG
1
;
Dong Soo CHA
;
Jun Hyung SOHN
;
Seung Jin CHOI
;
Kyoung Hee HAN
Author Information
1. Department of Obstetrics and Gynecology, Yonsei University, Wonju College of Medicine, Wonju, Kangwon-do, Korea.
- Publication Type:Original Article
- Keywords:
Apoptosis;
Feto-maternal interface;
TRAIL (Apo-2L)/TRAIL receptor system
- MeSH:
Apoptosis*;
Decidua;
Female;
Fertilization;
Gestational Trophoblastic Disease*;
Humans*;
Placenta;
Pregnancy;
Receptors, TNF-Related Apoptosis-Inducing Ligand;
Uterus
- From:Korean Journal of Obstetrics and Gynecology
2003;46(11):2156-2161
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Human uterus has been known as a immune privileged site for the product of conception. At the feto-maternal interface, Fas system is a underlying main mechanism of maternal immune acceptance. To date, the TRAIL (TNF-related apoptosis-inducing ligand) system is known to be another pivotal mechanism. OBJECTIVE: To clarify the protein expression of TRAIL ligand and receptors in the normal and pathologic (preeclampsia, hydatidiform mole) placenta, chorioamnion, decidua. METHODS: we investigated the expression of TRAIL system in the above-mentioned tissues by using Western Hybridization. RESULTS: All tissues expressed TRAIL ligand and only a DcR2 among TRAIL receptors (DR4, DR5, DcR1, DcR2). CONCLUSION: we demonstrated the expression of TRAIL ligand and DcR2 protein at the feto-maternal interface of the normal and pathologic pregnancies. Further study regarding the expression of other receptors and quantitative analysis between normal and pathologic pregnancies should be followed.
