An observation on the immune effect of hepatitis B vaccine by different immunization schedules among adults
- VernacularTitle:成人乙肝疫苗不同免疫程序效果观察
- Author:
Min-Jian GUO
1
;
Jun YAO
;
Jing LI
Author Information
1. 桐乡市疾病预防控制中心
- Keywords:
Adults;
Hepatitis B vaccine;
Immunization;
Immune effect
- From:
Journal of Preventive Medicine
2015;(8):757-760
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the immune effect of hepatitis B vaccine by different immunization schedules among adults,and to provide evidence for developing immunization strategy.Methods Adults aged 1 6 to 49 years with negative HBsAg and anti -HBs in Tongxiang city voluntarily received domestic or imported hepatitis B vaccine.These subjects were divided into 4 groups (Group A:1 0 μg domestic vaccine,0 -1 -3 schedule;group B:1 0 μg domestic vaccine,0 -1 -6 schedule;group C:1 0 μg imported vaccine,0 -1 -3 schedule;group D:1 0 μg imported vaccine,0 -1 -6 schedule). Quantitative detection of anti -HBs was conducted in 1 month and 1 year,and the anti -HBs positive rate and geometric mean titers of anti -HBs (GMT)were evaluated.Results A total of 848 subjects were evaluated.The anti -HBs positive rate was 99.76% after immunization in 1 month,and no significant differences were observed among different groups (P >0.05).The GMT of anti -HBs in group A was significantly lower than that of group C and B (P <0.05),while no significant differences were observed among group B and D.The GMT of anti -HBs was significantly decreased with ages. The anti -HBs positive rate was 70.28% after immunization in 1 year,which was significantly lower than that in 1 month after immunization.Conclusion Better immune effect could be achieved by 1 0 μg domestic hepatitis B vaccine with 0 -1-3 schedule.
