A study on the relationship between NAT2 genetic polymorphisms and biomarkers related to anti -tuberculosis drug -induced liver injury
- VernacularTitle:N -乙酰化转移酶2基因多态性与抗结核药物致肝损伤的关系研究
- Author:
Sen LIN
1
;
Shao-Hua TANG
;
Shao-Rong YAN
Author Information
1. 温州医科大学附属三院检验科
- Keywords:
N -acetyltransferase 2;
Genetic polymorphism;
Drug -induced liver injury;
Liver function
- From:
Journal of Preventive Medicine
2015;(6):564-567
- CountryChina
- Language:Chinese
-
Abstract:
Objective To know the relationship between NAT2 genetic polymorphisms and biomarkers related to anti -tuberculosis drug -induced liver injury (ATLI).Methods A total of 41 pulmonary tuberculosis patients with ATLI who received treatment within three months and 88 patients without ATLI were enrolled.The NAT2 genotypes were analyzed by pyrosequencing,and the biomarkers of liver function were analyzed.Results After anti -tuberculosis treatment,six biomarkers of liver function of pulmonary tuberculosis patients with different NAT2 genotypes were significantly higher than those before treatment(P <0.01 ).And there were significant differences in ALT level between different genotypes(P <0.05),the ALT levels of the fast acetylation genotype were significantly lower than that of the slow acetylation genotype(P<0.05 ),but no significant differences were observed in the other 5 biomarkers of liver function between different genotypes(P >0.05).Conclusion There is a certain relationship between NAT2 genetic polymorphisms and the elevated ALT levels among pulmonary tuberculosis patients after treatment.