A study on the effect of Ethyl Carbamate on the immune function of ICR mice
- VernacularTitle:氨基甲酸乙酯对小鼠免疫功能的影响
- Author:
Cai-Ju XU
1
;
De-Lei CAI
;
Yan-Hua SONG
;
Wei LU
;
Yu-Man CHEN
;
Ping-Gu WU
Author Information
1. 浙江省疾病预防控制中心
- Keywords:
Ethyl Carbamate;
ICR mice;
Immune function
- From:
Journal of Preventive Medicine
2015;(4):362-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of low dose Ethyl Carbamate (EC)on the immune function of ICR mice and to provide evidences for developing food safety standard.Methods The ICR mice were divided into four groups,and three groups were treated with 0.1 7,0.83,1 .67 mg/kg·bw EC respectively and the control group was treated with distilled water only.The immune function of ICR mice was determined by five aspects,including cellular immunity,humoral immunity,mononuclear macrophages's phagocytosis,natural killer cell activity and the organ coefficients of immune organs. Results Compared with the control group,the 1 .67 mg/kg·bw EC significantly inhibited the proliferation of spleen lymphocyte,natural killer cell activity and the hemolysis plaque -forming ability induced by ConA (P <0.05 ). Conclusion EC can cause the inhibition of normal mouse's immune function.
