A case -case control study on risk factors of the re -treatment multidrug resistant pulmonary tuberculosis
- VernacularTitle:复治肺结核发生耐多药危险因素的病例-病例对照研究
- Author:
Yu-Dong WEI
1
;
Song-Hua CHEN
;
Ying PENG
;
Jie-Ming ZHONG
;
Na LI
;
Xiao-Meng WANG
Author Information
1. 浙江省疾病预防控制中心
- Keywords:
Pulmonary tuberculosis;
Re -treatment MDR -TB;
Case -case control study
- From:
Journal of Preventive Medicine
2015;(2):124-126,130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of patients with re -treatment multidrug resistant pulmonary tuberculosis (MDR -TB)and to provide suggestions for intervention.Methods A case -case control study was carried out between patients with or without re -treatment MDR -TB,with a questionnaire interview and multivariate logistic regression analysis to explore the risk factors of re -treatment MDR -TB.Results A total of 172 patients were enrolled in this study including 99 re -treatment MDR -TB patients and 73 re -treatment non -MDR -TB patients(P >0.05).There was no significant difference between case group and control group in gender,age,residence and marital status.The sick time,the anti -tuberculosis treatment time,the number of anti -tuberculosis treatments,the rate of adverse reactions,history of taking isoniazid or rifampicin and the number of treatment interruption were higher in cases than those in control group(P <0.05),while the months of first -treatment were lower than those in control group(P <0.05).The number of anti -tuberculosis treatments(≥3),adverse reactions during treatment,the months of first -treatment were significant risk factors by the multivariable regression model,with the adjusted ORs and 95%CIs of 5.07 (1.89,13.64),4.27 (2.04, 8.94)and 2.35(1.06,5.22),respectively.Conclusion The number of anti -tuberculosis treatments,adverse reactions during treatment,the months of first -treatment were risk factors of patients with re -treatment MDR -TB.
