An observation on effect of different dosage booster immunization of hepatitis Bvaccine
- VernacularTitle:乙肝疫苗不同剂量加强免疫的效果观察
- Author:
Can-Lei LIU
1
;
Jun YAO
;
Mei-Fang SU
;
Yong-Di CHEN
;
Hai-Yun SHI
;
Yin-Xiang YIN
;
Jian-Bin SHANG
;
Dan CHEN
Author Information
1. 玉环县疾病预防控制中心
- Keywords:
Booster immunization;
Hepatitis Bvaccine;
Hepatitis A and Bcombined vaccine;
Immune effect
- From:
Journal of Preventive Medicine
2014;(11):1081-1084
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect on the booster immunization of different dosage of hepatitis B vaccine among children and to provide suggestions for booster immunization.Methods Children aged 5 -1 4 years old were randomly selected who had received the primary immunization of hepatitis B vaccine under 1 year old but had not received the booster immunization in Yuhuan county.A total of 547 children received 5 μg hepatitis A and B combined vaccine boost immunization and 688 children received 1 0 μg hepatitis B vaccine boost immunization in 2009.The anti -HBs levels before and after the boost immunization were detected.Results The anti -HBs positive rates of children received 5 μg and 1 0 μg vaccine boost immunization were 97.81 % and 96.08% respectively and the positive rates in the antibody negative children were 94.78% and 93.62% respectively.While the Geometric Mean Titer (GMT) of anti -HBs were 1 433.1 8 mIU /mL and 21 1 1 .43 mIU /mL respectively,which were both significantly higher than those before the boost immunization (P <0.001 ).The increase of GMT of children received 1 0 μg hepatitis B vaccine was significantly higher than that of children received 5 μg hepatitis A and B combined vaccine (P <0.05).Conclusion Both dosages of hepatitis B vaccine booster immunization are effective for children aged 5 -1 4 years old and 1 0 μg hepatitis B vaccine boost immunization has the better effect.
