The relationship between anti-cardiolipin antibodies and recurrent cerebral infarction
- VernacularTitle:抗心磷脂抗体与复发性脑梗死关系研究
- Author:
Zhi-Ying WANG
1
;
Zhi-Song XU
;
Xiao-Lan LUO
Author Information
1. 绍兴文理学院附属医院老年内科
- Keywords:
Anti-cardiolipin antibodies;
Cerebral infarction;
Recurrence
- From:
Journal of Preventive Medicine
2014;(10):1002-1004,1012
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum anti - cardiolipin antibodies( ACA ) and recurrent cerebral infarction( RCI),and to provide the clinical evidence for the prevention and treatment of RCI. Methods One hundred and ten patients with RCI,120 patients with primary cerebral infarction( PCI)and 150 healthy controls were recruited. Serum ACA was detected using quantitative enzyme linked immunosorbent assay( ELISA)and the positive rate of ACA was compared between these three patient groups. Results The positive rate of serum ACA of RCI group (31. 82%)was higher than that of PCI group( 15. 00%)( P <0. 05 ). Compared with patients above 50 years old (11. 56%),the patients under age of 50 had a higher positive rate of ACA( 57. 89%)( P <0. 05 ). There was no significant difference between males( 22. 52%)and females( 23. 53%) in positive rate of ACA( P > 0. 05 ). The recurrence rate(56. 25%)of ACA positive patients was higher than that of ACA negative patients(29. 79%)after one year follow up(P<0. 05). Conclusion Higher positive rate of serum ACA is observed in RCI patients. The PCI patients with high positive rate of serum ACA has an increased susceptibility for RCI. ACA detection is important for prediction and clinical intervention of the recurrence of cerebral infarction.