Lipoprotein lipase gene polymorphisms:associations with hypertension combined with obesity and their lipids metabolism
- VernacularTitle:脂蛋白脂酶基因多态性与高血压合并肥胖人群血脂的相关性研究
- Author:
Qing-Fang HE
1
;
Li-Xin WANG
;
Min YU
;
Ru-Ying HU
;
Wei-Wei GONG
;
Hao WANG
;
Jie ZHANG
;
Le FANG
;
Jing PAN
;
Dan-Ting SU
;
Ming-Bin LIANG
;
Ming ZHAO
Author Information
1. 浙江省疾病预防控制中心
- Keywords:
Hypertension combined with obesity;
Lipoprotein lipase;
Hind Ⅲ;
Polymorphism
- From:
Journal of Preventive Medicine
2014;(8):787-790,795
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the associations of lipoprotein lipase (LPL)gene Hind Ⅲ polymorphisms with hypertension combined with obesity and their lipids metabolism.Methods 326 subjects of hypertension combined with obesity and 326 healthy subjects were arranged to take questionnaires survey,physical examinations and blood biochemical tests.The LPL gene Hind Ⅲ polymorphisms were detected by PCR -RFLP.Regression analysis was used in this study. Results H +was the dominant allele in both groups.There was no significant difference among H +H +,H +H -, H -H -genotypes of LPL gene between the two groups (P >0.05).In the hypertension combined with obesity group, H +H +genotype had significantly higher triglyceride (TG),total cholesterol (TC)levels than H +H -/H -H -genotypes (P <0.05 )while no significantly different density lipoprotein cholesterol (HDLC)level (P >0.05 ).The results of conditional logistic regression analysis showed that high fasting blood glucose (FBG,adjusted OR =21.56, 95%CI:7.49 ~62.1 1 ),highTG(adjusted OR =7.5 1 ,95 % CI:4.20 ~1 3.43 ),lowHDLC(adjusted OR =2.67 ,95% CI:1.53 ~4.66),high uric acid (UA,adjusted OR =3.36 ,95% CI:1.55 ~7.29)and hypertension family history (adjusted OR =2.07,95% CI:1.21 ~3.55)were the main influencing factors of the hypertension combined with obesity (all P <0.05).Conclusion LPL Hind Ⅲ polymorphism is significantly associated with the lipids metabolism of the hypertension combined with obesity,but it is not an assured independent risk factor for hypertension combined with obesity.
