Effects of Insulin-like Growth Factor-I and 1,25-(OH)2 Vitamin D3 Concentration on Intrauterine Growth of Newborns from Mothers with Preeclampsia.
- Author:
In Sook YANG
1
;
Jung Hyun LEE
;
Hyung Shin LEE
;
So Young KIM
;
Sung Dong CHOI
;
In Kyung SUNG
;
Chung Sik CHUN
Author Information
1. Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. sinky@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Preeclampsia;
IGF-I;
1,25-(OH)2 vitamin D3;
Intrauterine growth retardation
- MeSH:
Birth Weight;
Cholecalciferol*;
Female;
Fetal Blood;
Fetal Development;
Fetal Growth Retardation;
Humans;
Infant, Newborn*;
Insulin-Like Growth Factor I;
Metabolism;
Mothers*;
Pre-Eclampsia*;
Pregnant Women;
Vitamins*
- From:Korean Journal of Pediatrics
2004;47(5):527-531
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was undertaken to observe the blood levels of IGF-I and 1,25-(OH)2 Vit. D3 in maternal and neonatal compartments and the effects of IGF-I concentration on intrauterine fetal growth and 1,25-(OH)2 Vit. D3 metabolism in the presence of preeclampsia. METHODS: Thirty-four full-term pregnant women with preeclampsia and their newborns(preeclampsia group) and 10 normotensive full-term pregnant women and their newborns(normotensive group) were observed. IGF-I and 1,25-(OH)2 Vit. D3 concentrations in maternal and umbilical cord blood were analysed. RESULTS: Maternal and umbilical cord blood levels of IGF-I and 1,25-(OH)2 Vit. D3 were significantly lower in the preeclampsia group than in the normotensive group. In the preeclampsia group, maternal and cord blood levels of IGF-I of small-for-gestational age newborns were significantly lower than those of appropriate-for-gestational age newborns. The birth weight and length of newborns correlated with IGF-I concentrations of maternal and umbilical cord blood in small-for-gestational age newborns of preeclampsia group. The correlation between IGF-I and 1,25-(OH)2 Vit. D3 was significant in the umbilical cord blood of preeclampsia group, but only in appropriate-for-gestational age newborns. CONCLUSION: It is suggested that the lower level of IGF-I is the primary factor of intrauterine growth retardation in preeclampsia, and the effect of IGF-I on the metabolism of 1,25-(OH)2 Vit. D3 is different according to the presence of preeclampsia and intrauterine fetal growth retardation.
