Association of Single Nucleotide Polymorphisms of REG1a Gene and Genetic Susceptibility of Gastric Carcinoma
10.3969/j.issn.1007-0931.2009.03.002
- VernacularTitle:REG1a基因单核苷酸多态性与胃癌遗传易感性研究
- Author:
Xin-Gang LI
1
;
Xiao-Guang LIU
;
Yun-Qing QIU
Author Information
1. 浙江大学医学院
- Keywords:
Gastric carcinoma;
Single nucleotide polymorphisms;
REG1a gene;
Genetic polymorphism;
Genetic susceptibility
- From:
Journal of Preventive Medicine
2009;21(3):4-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective Toinvestigate the association between genetic susceptibility of gastric carcinoma and single nucleotide polymorphism of REG1a gene in Chinese Han population. Methods The genotype of REG1a gene were detected by PCR and DNA sequencing in 183 Chinese patients with gastric carcinoma and 204 controls.Results It was found 3 new SNPs in REG1a gene at site 929(T/C),1790(C/G) and 2751(A/T), respectively; and the different genotypes of site 929 and 1790 were significant between gastric carcinoma patients and controls(P<0.05). Conclusions Sequencing of REG1a gene from specific population is available for screening candidate SNPs. The study reveals that the initially gastric carcinoma may be associated with site 929 and 1790. It provides a basis for further screening suitable SNPs labeling forecasting risk for gastric carcinoma.
