Diffusion ranges in human cutaneous tissue of botulinum toxin with two different concentrations
10.3760/cma.j.issn.1671-0290.2019.05.005
- VernacularTitle:两种浓度肉毒毒素在人体皮肤的弥散范围
- Author:
Ye ZHAO
1
;
Lei PAN
;
Hua WU
;
Sufan WU
Author Information
1. 浙江省人民医院整形外科/杭州医学院
- Keywords:
Botulinum toxins,type A;
Injections,intradermal;
Diffusion;
Minor's test
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2019;25(5):368-371
- CountryChina
- Language:Chinese
-
Abstract:
Objective The recommended concentration of botulinum toxin type A is 40 100 U/ml.This study observed diffusion areas of two different concentration (40 U/ml and 100 U/ml) of botulinum toxin type A with intradermal injection to provide data for clinical application.Methods Intradermal injections with two different concentrations of botulinum toxin type A were conducted in subjects' forearm,with each level 4 points,and 4U per point (40 U/ml as 0.1 ml,100 U/ml as 0.04 ml).Minor's tests were conducted in 2nd day,5th day,2nd week and every month between 1st to 9th month respectively.The anhidrosis areas were measured and then effects of both concentrations were compared.Results The round anhidrosis areas were found in 2nd day,reaching the maximum range nearly at 2nd week,and then gradually dimming from 6th month,and completely vanishing at 9th month.In different measured points,the definite anhidrosis areas of high concentration (100 u/ml) were 113,345,530,380,330,255,285,295 and 295 mm2 respectively,while the low concentration (40 u/ml) were 113,345,450,345,285,255,255,255 and 255 mm2 respectively.The results did not show significant difference.Conclusions Concentration and volume do not show significant influence on areas of sweat gland when botulinum toxin type A is injected intradermally in a certain dose.
