The advance of endogenous neural stem cell features for retinal Müller cell
10.3760/cma.j.issn.1005-1015.2019.05.023
- VernacularTitle:视网膜Müller细胞的内源性神经干细胞特性研究进展
- Author:
Yifeng KE
1
;
Longli ZHANG
;
Xiaorong LI
Author Information
1. 天津医科大学眼科医院、眼视光学院、眼科研究所天津市视网膜功能与疾病重点实验室 300384
- Keywords:
Neural stem cell;
Microglia;
Review;
Müller cells
- From:
Chinese Journal of Ocular Fundus Diseases
2019;35(5):522-524
- CountryChina
- Language:Chinese
-
Abstract:
Neural stem cell is a kind of stem cells that can differentiate into neural and glial cells. While Müller cells, the main endogenous neural stem cell in retina,have the features to reentry into the cell cycle and differentiate into neural cells after retinal damage. Although it is highly effective for retinal Müller cell differentiation spontaneously after retinal injury in vertebrates, this feature is rigorous restricted in mammals. Recently, some transcription factors,such as Ascl1, Sox2, Lin28, Atoh7, are sufficient to drive quiescent Müller cells back in proliferation to generate new retinal neurons. Moreover, combining Ascl1 expression with a histone deacetylase inhibitor can bypass the limitation and increase the generation of new neurons in the adult retina. These regenerated neurons integrate the existing neuronal network and are able to respond to light, indicating that they can likely be used to restore vision. While these results are extremely promising, the regenerative response is still limited, likely because the proliferative capacity of mammalian Müller cells is low compared to their zebrafish counterparts. It is indeed necessary to identify new factors increasing the efficiency of the regenerative response.
