Roles of innate lymphoid cells in tumor immunity and their clinical significance
10.3760/cma.j.issn.0254-5101.2019.09.013
- VernacularTitle:固有淋巴细胞在肿瘤免疫中的作用及其临床意义
- Author:
Changbin CHAI
1
;
Xi MA
;
Bang XIN
;
Yang WEN
;
Yang WANG
Author Information
1. 西安医学院分子病毒与病毒免疫学实验室
- Keywords:
Innate lymphoid cell;
Immuno-oncology;
Immunomodulation
- From:Chinese Journal of Microbiology and Immunology
2019;39(9):715-719
- CountryChina
- Language:Chinese
-
Abstract:
Innate lymphoid cells ( ILCs) are a recently characterized family of immune cells that have critical roles in innate immunity, immune regulation, maintenance of tissue homeostasis, and tissue re-pair and remodeling. Besides the conventional innate lymphocytes including NK cells and lymphoid tissue-in-ducer cells, the ILC family can be categorized into three groups, ILC1s, ILC2s and ILC3s. These non-cyto-toxic ILC subsets have been identified to confer a diverse array of functions in oncogenesis and metastasis, immune surveillance, and antitumor immunity. In this review, we summarized the emerging findings in re-cent years regarding the roles of ILCs in immuno-oncology, and highlighted their potentials in immunothera-peutic approaches to tumors.