Safety of yellow fever vaccine strain (Tiantan strain) in China and WHO vaccine strain 17D-213
10.3760/cma.j.issn.0254-5101.2019.09.003
- VernacularTitle:我国黄热病疫苗株(天坛株)与WHO疫苗株17 D-213的安全性研究
- Author:
Ling WANG
1
;
Na LI
;
Enyue FANG
;
Yue YIN
;
Yuhua LI
Author Information
1. 中国食品药品检定研究院虫媒病毒疫苗室
- Keywords:
Yellow fever;
Vaccine strain;
Intracerebral pathogenicity;
Safety
- From:Chinese Journal of Microbiology and Immunology
2019;39(9):657-661
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the intracerebral pathogenicity of the yellow fever vaccine strains of Tiantan strain used in China and WHO vaccine strain 17D-213 in mice. Methods Mice of different ages and strains were intracerebrally injected with same amount of Tiantan strain and 17D-213 strain. The death and survival of mice were observed and recorded. The LD50/ml and half survival time of the two vaccine strains were compared and analyzed. Results There was no difference in LD50/ml between the Tiantan strain and 17D-213 strain when used through intracerebral injection in one-day-old suckling mice, 7-9 g mice or 12-14 g mice. Moreover, no significant difference in survival trend was found in 7-9 g mice or 12-14 g mice injected with the two vaccine strains. However, the two strains had statistically different influences on the survival trend of one-day-old suckling mice. The half survival time of the Tiantan strain was 11 d, while that of the WHO vaccine strain 17D-213 was 6 d. Excepting in NIH mice, no significant differences in LD50/ml were detected between the same amount of two strains in BALB/c, KM, ICR or C57 mice. Con-clusions The yellow fever Tiantan vaccine strain and WHO vaccine strain 17D-213 have no significant difference in the intracerebral pathogenicity in mice of different ages and strains with good safety.