Pay attention to primary age?related tauopathy
10.3760/cma.j.issn.1006?7876.2019.10.001
- VernacularTitle:关注原发性衰老相关性tau蛋白病
- Author:
Zhiying WU
1
;
Qingqing TAO
Author Information
1. 浙江大学医学院附属第二医院神经内科
- Keywords:
Primary age?related tauopathy;
Alzheimer disease;
Pathology;
Clinical phenotype
- From:
Chinese Journal of Neurology
2019;52(10):793-796
- CountryChina
- Language:Chinese
-
Abstract:
Primary age?related tauopathy (PART) is a type of pathological change characterized by the deposition of tau protein in the brain confined to the entorhinal cortex and hippocampus (Braak stage 0-Ⅳ), with no or little amyloid?β protein (Aβ) deposition (Thal Aβ stage 0-2). In recent years, PART has received lots of attention, but its relationship with Alzheimer′s disease (AD) remains controversial. Therefore, strengthening the understanding of PART among clinicians and relevant researchers is of great value in interpretation of the relationship between brain aging and AD as well as other cognitive impairment diseases.
