Association of insulin sensitivity and β-cell function with body fat in patients with PCOS
10.3760/cma.j.issn.1000-6699.2019.10.010
- VernacularTitle:PCOS患者胰岛素敏感性、β细胞功能与体脂的关系
- Author:
Qizhi HAO
1
;
Hui CAO
;
Weimin WANG
;
Zhen ZHANG
Author Information
1. 河南省商丘市第一人民医院内分泌科 476100
- Keywords:
Polycystic ovary syndrome;
Insulin resistance;
β-cell function index;
miR-93;
Body fat content
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(10):864-866
- CountryChina
- Language:Chinese
-
Abstract:
A total of 187 patients with polycystic ovary syndrome (PCOS) in our hospital from January 2016 to December 2018 were enrolled, and 190 healthy people served as control group. The levels of homeostasis model assessment of insulin resistance index ( HOMA-IR), β-cell function index ( HOMA-β), total cholesterol ( TC), triglyceride (TG), low density lipoprotein-cholesterol ( LDL-C), high density lipoprotein-cholesterol ( HDL-C), body fat content ( BF), and miR-93 were compared between the two groups. The results showed that HOMA-IR, HOMA-β, TG, TC, LDL-C, BF, and miR-93 in PCOS group were significantly higher while HDL-C was significantly lower than those in control group (all P＜0.05). HOMA-IR, HOMA-β, TG, TC, and LDL-C levels in patients with Fat≥35% of PCOS group were significantly higher compared with those in patients with BF＜35% ( P＜0.05) while HDL-C was significantly lower (P＜0.05). There were no significant differences in TC and miR-93 between patients with BF≥35% and Fat＜35% in PCOS group (P＞0.05). HOMA-IR and HOMA-β were positively correlated with BF level (r=0.427 and 0.224, P＜0.05), while miR-93 was not correlated with BF level (P＞0.05).
