Cardioprotection induced by sevoflurane postconditioning in patients undergoing cardiac surgery with cardiopulmonary bypass: a meta-analysis
10.3760/cma.j.issn.0254-1416.2019.07.006
- VernacularTitle:七氟醚后处理对体外循环下心脏手术患者的心肌保护效应:meta分析
- Author:
Tianliang HOU
1
;
Jianrong YE
;
Long YANG
;
Hong ZHENG
Author Information
1. 新疆医科大学第一附属医院麻醉科
- Keywords:
Anesthetic,inhalation;
Cardiopulmonary bypass;
Ischemia-reperfusion;
Meta-analysis;
Postconditioning
- From:
Chinese Journal of Anesthesiology
2019;39(7):789-792
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically review the cardioprotection induced by sevoflurane postconditioning in the patients undergoing cardiac surgery with cardiopulmonary bypass.Methods Databases including Pubmed,EMBase,Web of Science,Cochrane Library,CBM,WangFang Data,CNKI and VIP were searched by a computer from the date of database establishment up to February 2019 and there was no limitation for language.The randomized control trials involving the cardioprotection induced by sevoflurane postconditioning in the patients undergoing cardiac surgery with cardiopulmonary bypass were collected.Evaluation indexes included:incidence of perioperative cardiac events,duration of intensive care unit stay,plasma concentrations of cardiac troponin I and creatine kinase-MB at 6 and 24 h after aortic opening,plasma concentrations of interleukin-6 at 2,12 and 24 h after aortic opening and percentage of spontaneous recovery of heart beat.Meta-analysis was conducted using the RevMan 5.3 and Stata 12.0 softwares.Results Seventeen randomized controlled trials involving 763 patients were included in our meta-analysis.Compared with control group,the incidence of reperfusion arrhythmia was decreased,the plasma concentrations of cardiac troponin I and creatine kinase-MB at 6 and 24 h after aortic opening and interleukin-6 at 2,12,and 24 h after aortic opening were decreased,the percentage of spontaneous recovery of heart beat was increased (P＜0.05 or 0.01),and no significant change was found in duration of intensive care unit stay in sevoflurane postconditioning group (P ＞ 0.05).Conclusion Sevoflurane postconditioning can produce cardioprotection in the patients undergoing cardiac surgery with cardiopulmonary bypass.
