New advances in drug therapy of chronic hepatitis B infection
10.3760/cma.j.issn.1674-2397.2019.05.014
- VernacularTitle:慢性乙型肝炎药物治疗研究若干新进展
- Author:
Yang ZHENG
1
;
Jianqin HE
;
Lanjuan LI
Author Information
1. 浙江大学医学院附属第一医院传染病诊治国家重点实验室 国家感染性疾病临床医学研究中心感染性疾病诊治协同创新中心
- Keywords:
Hepatitis B,chronic;
Antiviral agents;
Direct antiviral agents;
Immunotherapy
- From:
Chinese Journal of Clinical Infectious Diseases
2019;12(5):393-400
- CountryChina
- Language:Chinese
-
Abstract:
Nucleos( t) ide analogs and interferon are currently the main drugs for the treatment of chronic hepatitis B; they can induce sustained virologic suppression of HBV DNA , but still can’t clear HBsAg effectively.With the further understanding of the biology and life cycle of HBV and the breakthrough of direct antiviral agent for HCV treatment , multiple new drugs aiming at ＂cure HBV＂and clear HBsAg are undergoing preclinical development and ／or clinical trials.This article reviews the latest advances in drug therapy of chronic hepatitis B infection.
