Research progress on Akkermansia muciniphila in human intestine
10.3760/cma.j.issn.1674-2397.2019.05.013
- VernacularTitle:肠道 Akkermansia muciniphila 研究最新进展
- Author:
Longfei JIA
1
;
Li WU
;
Yuqiu HAN
;
Hanying LYU
;
Lijiang ZHANG
;
Baohong WANG
Author Information
1. 浙江工业大学长三角绿色制药协同创新中心
- Keywords:
Akkermansia muciniphila;
Intestinal microbiota;
Metabolic disease;
infectious disease
- From:
Chinese Journal of Clinical Infectious Diseases
2019;12(5):385-392
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies heve demonstrated that Akkermansia muciniphila (A.muciniphila) plays an important role in human health and disease , including regulating the development of the immune system and the metabolic phenotype of the host.This article reviews the research progress on A.muciniphila in recent years, focusing on the basic characteristics , the influencing factors of colonization , and the underlying mechanism of maintaining intestinal homeostasis of A.muciniphila.Additionally, the article summarizes the potential association between A.muciniphila and the chronic metabolic diseases such as obesity , atherosclerosis,diabetes mellitus and infectious diseases.The perspect of A.muciniphila as a new generation of probiotics in clinical medicine and the challenge for its industrialization are also discussed in the article .
