Research progress of BRAFV600E and TERT promoter mutations coexistence in papillary thyroid cancer

VernacularTitle:甲状腺乳头状癌中BRAFV600E与TERT启动子联合突变的研究进展
Author: Ying LIU ¹ ; Min LI ; Qiuqin QIAN ; Peng WEN ; Feng SHI
Author Information

1. 中南大学湘雅医学院附属肿瘤医院、湖南省肿瘤医院核医学科
Keywords: Thyroid neoplasms; Mutation; Proto-oncogene proteins B-raf; Telomerase; Trends
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2019;39(10):627-631
CountryChina
Language:Chinese
Abstract: Papillary thyroid cancer ( PTC) is the most common pathological type of thyroid cancer, and its morbidity raises rapidly in the global world. V-raf murine sarcoma viral oncogene homolog B1 ( BRAF) V600E mutation and telomerase reverse transcriptase ( TERT) promoter mutations are the most com-mon molecular markers of PTC. Nowadays, more and more studies find that the coexistence of BRAFV600E and TERT promoter mutations plays a synergistic role in the invasion and prognosis of PTC. This article re-views the recent advance in the synergism of BRAFV600E and TERT promoter mutations in PTC.