Progress of transcriptomics and proteomics in triple-negative breast cancer prognosis assessment

VernacularTitle:转录组学与蛋白组学在三阴性乳腺癌中的预后研究进展
Author: Pingmei HUANG ¹ ; Xiaolei HU ; Changsheng YE
Author Information

1. 南方医科大学南方医院乳腺中心(广州市510515
Keywords: triple-negative breast cancer (TNBC); transcriptomics; proteomics; prognosis
From: Chinese Journal of Clinical Oncology 2019;46(16):865-868
CountryChina
Language:Chinese
Abstract: s Triple-negative breast cancer (TNBC), a heterogeneous tumor that lacks the expression of estrogen receptor (ER), proges-terone receptor (PR), and human epidermal growth factor receptor 2 (HER2), is more aggressive and tends to recur or metastasize. In contrast to other breast cancer subtypes, no approved endocrine or targeted treatments exist for TNBC. Therefore, identification of the prognosis characteristisics and potential therapeutic targets of TNBC could facilitate early personalized treatment. Owing to the rapid development of various technologies, researchers are increasingly focusing on the integration of "big data" and biological sys-tems, which is referred to "omics," as means of resolving it . Here, we review the recent progress in transcriptomics and proteomics re-search on TNBC.