Clinical efficacy of apatinib for metastatic castration-resistant prostate cancer
10.3969/j.issn.1000-8179.2019.16.693
- VernacularTitle:甲磺酸阿帕替尼靶向治疗转移性去势抵抗性前列腺癌的临床疗效观察*
- Author:
Lili WANG
1
;
Bin HUO
;
Qing LIU
;
Lei WANG
;
Xiaodong HUO
;
Jinhuan WANG
;
Li ZANG
;
Haitao WANG
Author Information
1. 天津医科大学第二医院肿瘤科(天津市300211
- Keywords:
metastatic advanced castration-resistant prostate cancer (mCRPC);
apatinib;
efficacy;
adverse reactions
- From:
Chinese Journal of Clinical Oncology
2019;46(16):845-850
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the therapeutic effects and adverse events related to apatinib use among conventional, treatment-failed, advanced, metastatic castration-resistant prostate cancer (mCRPC). Methods: A total of 25 patients were treated with apatinib at The Second Hospital of Tianjin Medical University from June 2016 to December 2017. Clinical data were classified according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST). Pain relief evaluation, changes in serum prostate specific antigen (PSA), and adverse effects, were recorded. The evaluation period included 4 cycles (approximately 112 days). Results: The 25 patients were aged between 53 and 81 years (median: 72 years). All tumors were classified as adenocarcinomas in terms of histopathology. Classification of the therapeutic effect was as follows: 0 patients (0) had complete remission; 11 patients (44%) had partial remission;8 patients (32%) had stable disease; and 3 patients (12%) had progressive disease. The objective remission rate (ORR) was 44%, and the disease control rate (DCR) was 76%. Treatment-related adverse events were recorded for all patients: fatigue (n=22, 88%), gastroin-testinal symptoms (n=15, 60%), hypertension (n=7, 28%), hand-foot syndrome (n=6, 24%), dizziness, proteinuria, and others. Conclu-sions: Based on the demonstrated short-term therapeutic effects, apatinib could be a promising agent for conventional treatment-failed advanced CRPC. Adverse events are mild to moderate, and patients should be kept under observation and active management. To improve the effectiveness of apatinib treatment in the future, the mechanism of action of apatinib against mCRPC showld be ex-plored.
