Study on abnormity of gray matter volume in patients with obsessive compulsive disorder and its correlation with cognitive function and clinical symptoms
10.3969/j.issn.1002-0152.2019.10.004
- VernacularTitle:强迫障碍患者脑灰质体积改变及其与认知功能和临床症状的相关性
- Author:
Qihui NIU
1
;
Dehuan JIA
;
Mingmin NIU
;
Jingliang CHENG
;
Junhong LIU
;
Lei YANG
;
Youhui LI
Author Information
1. 郑州大学第一附属医院精神医学科 郑州450052
- Keywords:
Obsessive-compulsive disorder;
Magnetic resonance imaging;
Voxel-based morphometry;
Gray matter volume;
Cognitive function
- From:
Chinese Journal of Nervous and Mental Diseases
2019;45(10):595-601
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of gray matter volume in Obsessive Compulsive Disorder (OCD) patients compared with healthy controls, and to explore the correlation between brain regions with altered gray matter volume and the patients'cognitive function and clinical symptoms. Method Thirty-six patients with first-episode OCD and 35 healthy controls who were matched by age, gender and education level were selected and examined by MATRICS Consensus Cognitive Battery (MCCB) and Yale-Brown Obsessive Compulsive Scale (Y-BOCS). The head MRI and the Voxel-based morphometry was used to test the volume of gray matter. The correlation analysis was conducted to analyze the correlation between brain areas with altered gray matter volume and patients'cognitive function and Y-BOCS results. Results Compared with the control group, the OCD group had increased gray matter volume in frontal parietal lobe (postcentral gyrus-L, precentral gyrus-L) (t=4.299, P<0.0005, voxels>100) and temporal-limbic system (fusiform gyrus-L, superior temporal gyrus-L, medial temporal lobe-L, parahippocampal gyrus-L) (t=4.841, P<0.0005, voxels> 100). Meanwhile, the volume of gray matter decreased in bilateral anterior cingulate gyrus (t=-4.181, P<0.0005, voxels>100). In the case group, there were a positive correlation between the volume of gray matter in the temporal lobo-limbic system and social cognition score (r=0.347,P=0.038) and a positive correlation between the volume of gray matter in the anterior cingulate gyrus and obsessions score (r=0.416,P=0.012). Conclusion Patients with OCD have abnormal gray matter volume in a wide range of brain regions, including the frontal parietal lobe, the temporal-limbic system, and bilateral anterior cingulate gyrus, among which the volume of gray matter in the temporal-limbic system is correlated with social cognition, and gray matter volume in the anterior cingulate gyrus is correlated with obsessions.
