Preparation and properties of alkalized shikonin liposome
10.3969/j.jssn.1006-0111.2019.01.016
- VernacularTitle:紫草素钠脂质体的制备及性能研究
- Author:
Lei SHI
1
;
Jun YE
;
Lei SONG
Author Information
1. 上海市静安区食品药品检验所
- Keywords:
liposome;
radixlithospermi;
L-shikonin;
in vitro release property
- From:
Journal of Pharmaceutical Practice
2019;37(1):69-73
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the preparation and properties of alkalized shikonin liposome.Methods Alkalized shikonin was purified from extracts of radix lithospermi with an alkali solution and acid formulation, and then the alkalized shikonin liposome was prepared by ethanol injection.The morphology, particle size and Zeta potential were determined, and the encapsulation efficiency and the in vitro release property were investigated.The content of L-shikonin was also measured by High Performance Liquid Chromatography.Results Alkalized shikonin liposome presented even sphere and normal distribution with particle size of 104.2nm.The Zeta potential was-14.8mV.L-shikonin was linear in the range of 5-50mg/L with the correlation coefficient 0.999 9.The encapsulation efficiency was 43.67％.The final release rate was 65.82％.Conclusion Alkalized shikonin liposome was prepared successfully with good entrapment efficiency and in vitro release property.
