Research advance on the interaction of pharmaceutical molecules with target proteins
10.3969/j.issn.1006-0111.2019.01.001
- VernacularTitle:药物分子与靶蛋白相互作用的研究进展
- Author:
An LI
1
;
Xiaoqing ZHOU
;
Kuo SUN
;
Jinru YANG
;
Yongfei ZHU
;
Yiming LU
Author Information
1. 海军军医大学药学院
- Keywords:
interaction;
target protein;
drug screening;
affinity;
binding sites
- From:
Journal of Pharmaceutical Practice
2019;37(1):1-4,31
- CountryChina
- Language:Chinese
-
Abstract:
The function of drugs is based on the interaction between drug molecules and their targets.Qualitative analysis and quantitative detection of drug-target interactions run through the whole process from drug discovery to clinical practice.After decades of development, the study methods on the interaction between drug molecules and target proteins have been transformed from traditional biochemical experiments to a diversity of efficient and accurate technology systems supported by advanced molecular biology and biophysics theory.In this review, representative methods and techniques were introduced from aspects of target discovery and validation, affinity determination, interaction sites and structural analysis, which might provide some references for drug discovery and mechanism exploration.
