Pharmacodynamics of the effective anti-hypoxia constituents in Saussurea involu-crat a
10.3969/j.issn.1006-0111.2018.03.012
- VernacularTitle:大苞雪莲有效成分的抗缺氧药效学研究
- Author:
Huiping MA
1
;
Xin WANG
;
Ningzi WU
;
Linlin JING
;
Zhengping JIA
;
Jun ZHANG
Author Information
1. 兰州总医院全军高原环境损伤防治重点实验室
- Keywords:
Saussurea involucrata;
anti-hypoxia activity;
petroleum ether extract;
octacosane
- From:
Journal of Pharmaceutical Practice
2018;36(3):247-249,254
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study pharmacodynamics of the effective anti-hypoxia components in the petroleum ether ex-tract of Saussurea Involucrate(PESI)and octacosane.Methods PESI and octacosane were first evaluated by normobaric hy-poxia model,acute decompression model and followed by chemical induced hypoxic models with potassium cyanide,sodium ni-trite and isoprenaline hydrochloride poisoning.Results PESI and octacosane can effectively prolong the survival time of hypo-baric hypoxic mice(P<0.01)and reduce the mortality of acute hypobaric hypoxia mice(P<0.01)in a dose-dependent man-ner.Anti-hypoxic potency of PESI and octacosane obtained by chemical induced hypoxic model indicated that they significantly increase survival time(P<0.05)of hypoxia mice than acetazolamide.Conclusion PESI and octacosane have good anti-hypoxia activity.
