Effects of the active constituents from Saussurea involucrata on metabolism of mice at simulated high altitude
10.3969/j.issn.1006-0111.2018.03.011
- VernacularTitle:大苞雪莲抗缺氧有效成分对模拟高原缺氧小鼠物质代谢的影响
- Author:
Huiping MA
1
;
Ningzi WU
;
Xin WANG
;
Linlin JING
;
Zhengping JIA
;
Jun ZHANG
Author Information
1. 兰州总医院全军高原环境损伤防治重点实验室
- Keywords:
Saussurea involucrata;
anti-hypoxia activity;
metabolism;
petroleum ether extract;
octacosane
- From:
Journal of Pharmaceutical Practice
2018;36(3):243-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-hypoxia effects of octacosane and the petroleum ether extract from Saus-surea Involucrate(PESI)on the water,sugar,lipid and protein metabolism of mice at simulated high altitude.Methods The healthy adult male BALB/C mice were randomly divided into normal control group,hypoxic model group,acetazolamide group, the petroleum ether of Saussurea involucrata group and octacosane group.Drugs were administered i.v 20 mins before the mice were exposed to a simulated high altitude of 6 000 m for 8 hours in an animal decompression chamber.The mice were sacrificed at the end of 8 hours.Organ water content,organ indexes and metabolism indicators of sugar,protein and lipid were deter-mined.Results The edema of heart,brain and lung was reduced notably(P<0.05,P<0.01)in the mice received PESI at 200 mg/kg and octacosane at 100 mg/kg.In the treated groups,the increase of blood sugar,muscle glycogen,TG(triglycer-ide),TC(total cholesterol)were all significantly inhibited,the decrease of liver glycogen,the protein content of heart and brain was also remarkably blocked(P<0.05,P<0.01).Conclusion PESI and octacosane effectively regulate the metabolism of hypoxic mice and reserve the body′s energy for survival by lowering the basic metabolism.
